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Chronic osteomyelitis due to Clostridium difficile.

T V Riley, K T Karthigasu

British Medical Journal (Clinical Research Ed.)

|April 24, 1982

Summary

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This study reports a rare case of chronic femoral osteomyelitis caused by Clostridium difficile, an anaerobic bacterium. Successful treatment was achieved using metronidazole despite initial penicillin resistance.

Area of Science:

Infectious Diseases
Orthopedics
Microbiology

Background:

Anaerobic bacterial osteomyelitis is uncommon.
Clostridium difficile is typically associated with gastrointestinal issues, not bone infections.

Observation:

A patient presented with chronic osteomyelitis of the femur.
Clostridium difficile was repeatedly isolated from the infection site over several months.
The bacteria initially sensitive to penicillin developed resistance during treatment.

Findings:

This case may represent the first instance of Clostridium difficile causing femoral osteomyelitis.
Persistent isolation of C. difficile could be attributed to resistant spores.
The likely source was the patient's gastrointestinal tract, despite the absence of symptoms.

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Implications:

Highlights the potential for C. difficile to cause rare forms of osteomyelitis.
Suggests the need for considering anaerobic bacteria in refractory bone infections.
Metronidazole proved effective in treating this challenging Clostridium difficile osteomyelitis case.