Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[X-chromosome-linked hereditary dermatoses].

R Happle

    Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
    |February 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    The Lyon effect complicates X-linked inheritance, but aids in detecting female carriers for some genetic skin disorders. Prenatal diagnosis is possible for severe X-linked conditions.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Frontal fibrosing alopecia sparing a dermal melanocytic nevus: a report of two cases of Renbök phenomenon.

    Journal of the European Academy of Dermatology and Venereology : JEADV·2022
    Same author

    White lentiginosis of Grosshans: which mode of inheritance?

    Journal of the European Academy of Dermatology and Venereology : JEADV·2021
    Same author

    Phylloid hypermelanosis: further report of an unusual syndrome.

    Journal of the European Academy of Dermatology and Venereology : JEADV·2021
    Same author

    Two examples of Renbök phenomenon in dermatophytosis sparing congenital nevi.

    Journal of the European Academy of Dermatology and Venereology : JEADV·2021
    Same author

    A proposed new category of cutaneous segmental mosaicism: Isolated segmental biallelic monoclonal mosaicism.

    Journal of the European Academy of Dermatology and Venereology : JEADV·2020
    Same author

    Flag-like hypermelanosis with superimposed lichen sclerosus et atrophicus: an unusual Koebner phenomenon?

    Journal of the European Academy of Dermatology and Venereology : JEADV·2020
    Same journal

    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·2022
    Same journal

    [Viral infections of the skin].

    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·2022
    Same journal

    [Viral exanthems in children].

    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·2022
    Same journal

    [Erratum to: Digital health applications and data protection].

    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·2022
    Same journal

    [Virus-induced exanthems in returning travellers].

    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·2022
    Same journal

    [Venous ulcus cruris-Surgical treatment].

    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·2022
    See all related articles

    Area of Science:

    • Genetics
    • Dermatology
    • Molecular Biology

    Context:

    • X-linked inheritance patterns are complex due to the Lyon effect (X-inactivation).
    • This phenomenon impacts the manifestation and detection of various genetic disorders.
    • Understanding these mechanisms is crucial for genetic counseling and diagnosis.

    Purpose:

    • To explore how the Lyon effect influences the expression and detection of X-linked genetic disorders.
    • To differentiate between X-linked recessive and dominant conditions and their inheritance patterns.
    • To highlight diagnostic approaches, including carrier detection and prenatal diagnosis.

    Summary:

    • The Lyon effect blurs dominant/recessive distinctions in X-linked inheritance, enabling heterozygote detection in some recessive genodermatoses via clinical or enzymatic methods.

    Related Experiment Videos

  • X-linked recessive ichthyosis, despite escaping X-inactivation, allows heterozygote detection through enzyme analysis.
  • X-linked dominant disorders like keratosis follicularis spinulosa decalvans and Bazex syndrome affect both sexes, while others (incontinentia pigmenti, etc.) are male-lethal.

    • Impact:

    • Facilitates carrier detection in females for specific X-linked genodermatoses.
    • Enables prenatal diagnosis for severe X-linked conditions when the cellular defect is known.
    • Informs genetic counseling and management strategies for families affected by X-linked disorders.