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Related Experiment Videos

Sustained flexibility in infant feeding tubes containing nonmigrating plasticizer.

G R Pereira, R Herold, M Ziegler

    JPEN. Journal of Parenteral and Enteral Nutrition
    |January 1, 1982
    PubMed
    Summary

    Newborn feeding tubes made with ti-octyltrimellitate (TOTM) plasticizer maintain flexibility, unlike those with di-octylphthalate (DOP). This sustained flexibility enhances safety for infant enteral nutrition.

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    Area of Science:

    • Biomaterials Science
    • Pediatric Gastroenterology
    • Medical Device Engineering

    Background:

    • Polyvinyl chloride (PVC) feeding tubes plasticized with di-octylphthalate (DOP) can develop stiffness, leading to medical complications.
    • Stiffness in feeding tubes can impact patient comfort and efficacy of enteral feeding, particularly in vulnerable infant populations.

    Purpose of the Study:

    • To evaluate the flexibility of PVC feeding tubes manufactured with a nonmigrating plasticizer, ti-octyltrimellitate (TOTM).
    • To compare the stiffness development of TOTM-plasticized PVC tubes against traditional DOP-plasticized PVC tubes in infant use.

    Main Methods:

    • Two sizes (#5 French and #8 French) of both DOP and TOTM PVC feeding tubes were assessed.
    • Tube stiffness was monitored over 5 to 8 days of use in infant patients.

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  • Placement location (stomach vs. jejunum) and patient factors were analyzed for correlation with stiffness.

    • Main Results:

    • #5 French DOP tubes showed significant stiffening within 1-2 days, worsening up to 8 days.
    • Stiffness in #5 French DOP tubes was greater when placed in the jejunum compared to the stomach.
    • #5 French TOTM tubes and all #8 French tubes (DOP and TOTM) maintained flexibility throughout the study period.

    Conclusions:

    • Ti-octyltrimellitate (TOTM) plasticized PVC feeding tubes demonstrate sustained flexibility.
    • The use of TOTM offers a significant improvement in maintaining tube flexibility, enhancing the safety of enteral feeding for newborn infants.