Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Transitions in extracellular macromolecules during avian ocular development.

B P Toole

    Progress in Clinical and Biological Research
    |January 1, 1982
    PubMed
    Summary

    Avian ocular development involves dynamic changes in extracellular matrix components like collagen and proteoglycans in the cornea and vitreous. These shifts are crucial for tissue hydration, transparency, and structural integrity.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    CD73 complexes with emmprin to regulate MMP-2 production from co-cultured sarcoma cells and fibroblasts.

    BMC cancer·2019
    Same author

    Cooperative roles for emmprin and LYVE-1 in the regulation of chemoresistance for primary effusion lymphoma.

    Leukemia·2011
    Same author

    Extracellular matrix metalloproteinase inducer regulates metalloproteinases in human uterine endometrium.

    The Journal of clinical endocrinology and metabolism·2006
    Same author

    Hyaluronan and hyaluronan-binding proteins. Probes for specific detection.

    Methods in molecular biology (Clifton, N.J.)·2001
    Same author

    Tumorigenic potential of extracellular matrix metalloproteinase inducer.

    The American journal of pathology·2001
    Same author

    Hyaluronan in morphogenesis.

    Seminars in cell & developmental biology·2001

    Area of Science:

    • Ophthalmology
    • Developmental Biology
    • Biochemistry

    Background:

    • The extracellular matrix (ECM) of avian ocular tissues undergoes significant transformations during development.
    • Key components include glycosaminoglycans and collagens in the cornea and vitreous body.

    Purpose of the Study:

    • To investigate the developmental transitions of macromolecular ECM components in avian ocular tissues.
    • To understand the roles of collagen and proteoglycans in corneal and vitreous development.

    Main Methods:

    • Analysis of macromolecular composition (collagens, proteoglycans, hyaluronate) during avian ocular development.
    • Histological and biochemical examination of corneal and vitreous tissues at different developmental stages.

    Main Results:

    • Early cornea: acellular stroma with type I/II collagen, chondroitin sulfate-proteoglycan; basement membrane with type IV collagen.
    • Developing cornea: mesenchymal cells produce hyaluronate, differentiate into fibroblasts synthesizing type I collagen and keratan sulfate-proteoglycans; hyaluronidase activity increases, leading to transparency.
    • Vitreous body: develops with chondroitin sulfate and type II collagen, initially from neural retina, later from vitreous cells.

    Conclusions:

    • ECM macromolecular transitions are critical for avian eye development, influencing tissue hydration, transparency, and structural organization.
    • These components play roles in stabilizing tissue phenotype and guiding cellular migration during development.

    Related Experiment Videos