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"Symptomless" autoimmune thyroiditis in depression.

M S Gold, A L Pottash, I Extein

    Psychiatry Research
    |June 1, 1982
    PubMed
    Summary
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    Symptomless autoimmune thyroiditis (SAT) may present with psychiatric symptoms like depression. Thyroid dysfunction was found in 15% of psychiatric patients, suggesting SAT is not symptomless.

    Area of Science:

    • Endocrinology
    • Psychiatry
    • Immunology

    Background:

    • Thyroid-stimulating hormone (TSH) response to thyrotropin-releasing hormone (TRH) aids in identifying thyroid failure.
    • Hashimoto's thyroiditis, symptomless autoimmune thyroiditis (SAT), and subclinical hypothyroidism are common in these patients.
    • SAT patients are clinically euthyroid but may exhibit psychiatric symptoms.

    Purpose of the Study:

    • To test the hypothesis that SAT presents with psychiatric symptoms.
    • To evaluate the prevalence of thyroid dysfunction in psychiatric patients.

    Main Methods:

    • 100 psychiatric hospital admissions complaining of depression or lack of energy were tested.
    • Thyroid function tests included thyroxin (T4), T3 resin uptake (RU), T3 radioimmunoassay (T3RIA), TSH, and TRH tests.

    Related Experiment Videos

  • Thyroid microsomal antibodies were measured.
  • Main Results:

    • 15% of patients met criteria for subclinical, mild, or overt hypothyroidism.
    • Of these, 60% had positive thyroid microsomal antibodies (≥1:10 titer).

    Conclusions:

    • Symptomless autoimmune thyroiditis (SAT) is not truly symptomless and can manifest psychiatrically.
    • SAT should be considered in the evaluation of patients with depression, anergy, or atypical psychiatric presentations.