Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Human endocrine responses to acceleration stress.

F J Mills, V Marks

    Aviation, Space, and Environmental Medicine
    |June 1, 1982
    PubMed
    Summary

    Acceleration stress significantly alters cortisol levels and plasma volume in healthy males, while other hormones remain unchanged. This study investigates the specific endocrine responses to G-force exposure.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The radioimmunoassay of tricyclic antidepressants.

    British journal of clinical pharmacology·2012
    Same author

    A comprehensive review of oral glucosamine use and effects on glucose metabolism in normal and diabetic individuals.

    Diabetes/metabolism research and reviews·2011
    Same author

    A response.

    Journal of the Royal Society of Medicine·2010
    Same author

    Radioimmunoassays [abridged].

    Proceedings of the Royal Society of Medicine·2010
    Same author

    Pituitary-adrenal Function in Cases of Pituitary Tumour.

    British medical journal·2010
    Same author

    Nutrient regulation of the enteroinsular axis and insulin secretion.

    Nutrition research reviews·2008

    Area of Science:

    • Aerospace Medicine
    • Endocrinology
    • Human Physiology

    Background:

    • Acceleration stress is a critical factor in aerospace and high-performance activities.
    • Understanding hormonal responses to G-force is vital for crew safety and performance.
    • Previous research has yielded varied results on endocrine system's reaction to G-loads.

    Purpose of the Study:

    • To investigate the impact of acute acceleration stress on peripheral blood hormone concentrations.
    • To identify specific hormones affected by +Gz exposure.
    • To analyze changes in plasma volume during and after acceleration.

    Main Methods:

    • Five healthy male volunteers were exposed to +6 Gz for 1 minute.
    • Peripheral blood samples were collected to measure hormone levels (GH, PRL, TSH, LH, FSH, cortisol).
    • Plasma volume changes were assessed concurrently with hormonal assays.

    Main Results:

    • No significant changes were observed in Growth Hormone (GH), Prolactin (PRL), Thyroid-Stimulating Hormone (TSH), Luteinizing Hormone (LH), and Follicle-Stimulating Hormone (FSH) levels.
    • Serum cortisol levels showed a highly significant increase (p < 0.001) post-acceleration, peaking 20 minutes after exposure.
    • Plasma volume experienced significant reductions (p < 0.001) at the end of the acceleration period.

    Conclusions:

    • Acceleration stress elicits a specific endocrine response, primarily affecting cortisol and plasma volume.
    • The lack of change in other tested pituitary and gonadal hormones suggests a targeted physiological response to G-force.
    • Further research is warranted to elucidate the mechanisms behind the observed specificity of hormonal regulation under G-load.

    Related Experiment Videos