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Related Experiment Videos

Structure of the cell surface.

S J Singer

    National Cancer Institute Monograph
    |January 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    The cell surface has a three-layered structure involving the plasma membrane, exoskeleton, and membrane cytoskeleton. This structure is crucial for cell functions and interactions, with protein binding mediating its organization.

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    Area of Science:

    • Cell Biology
    • Biochemistry
    • Molecular Biology

    Background:

    • The cell surface is vital for cellular functions and interactions.
    • It features a three-layered structure: plasma membrane, outer exoskeleton, and inner membrane cytoskeleton.
    • The fluid mosaic model approximates the plasma membrane's molecular structure.

    Purpose of the Study:

    • To elucidate the molecular mechanisms underlying the three-layered cell surface structure.
    • To investigate changes in cell surface organization during neoplastic transformation.
    • To understand alterations in cell shape, adhesiveness, and contact inhibition.

    Main Methods:

    • Analysis of molecular structures of cell surfaces.
    • Comparative studies of normal fibroblasts and virus-transformed fibroblasts.

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  • Investigation of protein-membrane interactions.

    • Main Results:

    • Protein binding is identified as the basis for the cell surface's three-layered organization.
    • Molecular mechanisms driving changes in cell shape and adhesiveness are being revealed.
    • Insights into contact inhibition of motility in transformed cells are emerging.

    Conclusions:

    • The three-layered cell surface structure is fundamentally organized by specific protein interactions.
    • Understanding these molecular mechanisms is key to comprehending neoplastic transformation.
    • Further research will illuminate the roles of cell surface components in cancer development.