Suppression of PHA-induced IFN-gamma production in BALB/c mice

In the present paper we report some evidences of negative genetic control of the IFN-gamma production following stimulation with phytohaemagglutinin both in vivo and in vitro. C3H mice were good IFN-gamma producers whereas BALB/c and (BALB/c X C3H) F1 mice were non producers. The distribution of the capacity to produce significant levels of IFN-gamma in [(C3H X BALB/c) X (C3H X BALB/c)] F2 mice is compatible with the hypothesis of a pleomorphic negative control.