[Results of gonadotropin therapy in hypogonadotropic anovulation]

Combined FSH and HCG treatment was applied to patients in whom anovulation had been found to be the cause of sterility. Results were separately evaluated for patients in normal gonadotrophic conditions, on the one hand, and those in hypogonadotrophic conditions, on the other. They were compared with findings obtained from other groups between which no distinction had been possible due to the use of earlier methods for gonadotrophin determination. Lower RIA values for FSH or LH seemed to be more promising in terms of therapeutic success, with gravidity having been recorded from 44 per cent of hypogonadotrophic patients. The conclusion was drawn that prolactin-, FSH- or LH-RIA methods should be practicable for optimum treatment on a routine basis of patients with sterility due to anovulation. The data reported in this paper were derived from 54 patients in 117 therapeutic series.