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Multiple myeloma first observed as multiple cutaneous plasmacytomas.

A Shah, P Klimo, A Worth

    Archives of Dermatology
    |November 1, 1982
    PubMed
    Summary
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    Multiple cutaneous plasmacytomas, rare skin tumors, can indicate underlying multiple myeloma. This case highlights that skin lesions may precede bone or marrow involvement in this plasma cell disorder.

    Area of Science:

    • Oncology
    • Dermatology
    • Hematology

    Background:

    • Multiple myeloma is a plasma cell malignancy.
    • Cutaneous plasmacytomas are rare manifestations, particularly when multiple.
    • Early detection is crucial for patient outcomes.

    Observation:

    • A 62-year-old woman presented with multiple skin plasmacytomas.
    • Initial evaluation showed no evidence of multiple myeloma in bone or marrow.
    • Elevated serum IgA-lambda levels were noted.

    Findings:

    • Skin lesions regressed with melphalan treatment.
    • Recurrence occurred with lytic bone lesions 10 months later.
    • The patient succumbed to bronchopneumonia 11 months after initial presentation.

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    Implications:

    • Multiple cutaneous plasmacytomas can be an early sign of multiple myeloma.
    • This case underscores the importance of monitoring patients with skin plasmacytomas.
    • Further research into the progression of cutaneous plasmacytomas is warranted.