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Clinical and laboratory findings in Metation EK-50
Czechoslovak Medicine
|January 1, 1982
Summary
Occupational exposure to fenitrothion (Metation EK-50) caused neurological and biochemical changes in workers. Health effects included parasympathetic stimulation, pseudoneurasthenic syndrome, and impaired cognitive functions.
Area of Science:
- Occupational Health
- Toxicology
- Epidemiology
Background:
- Fenitrothion (Metation EK-50) is an organophosphate insecticide.
- Workers in fenitrothion production and packing are occupationally exposed.
- Long-term health effects of fenitrothion exposure require investigation.
Purpose of the Study:
- To evaluate the health effects of occupational fenitrothion exposure.
- To assess clinical, neurological, psychiatric, psychodiagnostic, and biochemical changes.
- To quantify fenitrothion exposure levels through urinary metabolite analysis.
Main Methods:
- Epidemiological study over 5 years.
- Clinical examinations, neurological and psychiatric assessments.
- Psychodiagnostic tests and biochemical analyses (cholinesterase, GPT, LDH5, protein fractions).
- Urinary p-nitro-m-cresol (NC) analysis to estimate exposure.
Main Results:
- Clinical signs of parasympathetic stimulation and hypotonia observed.
- Low-grade pseudoneurasthenic syndrome in 33% of females and 15% of males.
- Impaired retention, visuomotor coordination, decision-making, and reaction time.
- Significant biochemical changes: cholinesterase inhibition, elevated GPT and LDH5, altered protein fractions (P < 0.001).
- Elevated urinary NC levels in exposed workers, indicating significant fenitrothion intake (approx. 15-20 mg/day).
Conclusions:
- Occupational exposure to fenitrothion leads to significant health impairments.
- Workers exhibit neurological, psychiatric, and biochemical alterations.
- Urinary NC is a reliable biomarker for assessing fenitrothion exposure and its health impact.