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Midazolam for the intravenous induction of anaesthesia in children

A M Holloway, D G Jordaan, J G Brock-Utne

    Anaesthesia and Intensive Care
    |November 1, 1982
    PubMed

    Insights

    Midazolam is a safe and effective intravenous anesthetic induction agent for children, offering a viable alternative to thiopentone for minor surgeries.

    Area of Science:

    • Pediatric Anesthesiology
    • Pharmacology
    • Surgical Procedures

    Background:

    • Intravenous anesthetic induction agents are crucial for pediatric surgical procedures.
    • Thiopentone has been a standard induction agent, but alternatives are sought.
    • Assessing the safety and efficacy of midazolam in pediatric anesthesia is important.

    Purpose of the Study:

    • To compare midazolam with thiopentone as an intravenous anesthetic induction agent in children.
    • To evaluate induction time and incidence of apnea for both agents.
    • To determine if midazolam is a suitable alternative to thiopentone in pediatric minor surgery.

    Main Methods:

    • A comparative study involving children aged 4-12 years undergoing elective minor surgery.
    • Administration of midazolam or thiopentone for anesthetic induction.
    • Monitoring of induction time and incidence of apnea.

    Main Results:

    • Successful anesthetic induction was achieved with both midazolam and thiopentone.
    • Midazolam induction time was longer than thiopentone, but not statistically significant.
    • The incidence of apnea was greater with thiopentone, though not statistically significant.

    Conclusions:

    • Midazolam is an effective and safe intravenous anesthetic induction agent for pediatric patients.
    • Midazolam presents a reasonable alternative to thiopentone for induction in children undergoing minor elective operations.

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