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[Diffuse pulmonary amylosis. Apropos of 2 cases associated with Waldenstrom's disease]
Le Poumon Et Le Coeur
|January 1, 1982
Abstract:
Diffuse pulmonary amyloidosis is rarely reported in systemic amyloidosis. We report two patients with Waldenström's macroglobulinemia in whom pulmonary amyloidosis was revealed by a diffuse interstitial syndrome without severe functional impairment. Amyloid pulmonary deposits are anatomically frequent and are often associated with cardiac amyloidosis. They must be evoked more frequently in the diagnosis of diffuse interstitial patterns, particularly in patients with primary amyloidosis or dysglobulinemia.
Insights
Diffuse pulmonary amyloidosis is uncommon in systemic conditions. This study highlights two Waldenström
Area of Science:
- Pulmonary Medicine
- Hematology
- Pathology
Background:
- Systemic amyloidosis can affect the lungs, but diffuse pulmonary involvement is rare.
- Waldenström's macroglobulinemia is a lymphoproliferative disorder associated with amyloidosis.
Observation:
- Two patients with Waldenström's macroglobulinemia presented with diffuse interstitial lung disease.
- Pulmonary symptoms were not severe in these cases.
Findings:
- Pulmonary amyloidosis was diagnosed in both patients.
- Amyloid deposition in the lungs is anatomically common and often linked to cardiac amyloidosis.
Implications:
- Pulmonary amyloidosis should be considered in the differential diagnosis of diffuse interstitial lung patterns.
- Early consideration is crucial, especially in patients with primary amyloidosis or dysglobulinemia.