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Related Experiment Videos

Andropause: incidence and pathogenesis.

I Mastrogiacomo, G Feghali, C Foresta

    Archives of Andrology
    |December 1, 1982
    PubMed
    Summary
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    Andropause, or male menopause, is not inevitable and presents varied hormonal profiles. Studies show diverse patterns of luteinizing hormone (LH) and testosterone levels in aging men.

    Area of Science:

    • Endocrinology
    • Reproductive Health
    • Aging

    Background:

    • Aging in men is associated with hormonal changes, but the concept of 'andropause' is debated.
    • Understanding the hormonal profiles of aging men is crucial for diagnosing and managing potential conditions.
    • Previous studies have indicated variability in hormone levels among older men.

    Purpose of the Study:

    • To investigate the hormonal profiles of aging men, specifically focusing on gonadotropins and androgens.
    • To categorize older men into distinct groups based on luteinizing hormone (LH) and testosterone (T) levels.
    • To explore the variability in the pathogenesis and hormonal aspects of andropause.

    Main Methods:

    • Radioimmunoassay (RIA) was used to measure plasma levels of LH, FSH, T, E2, and A in 145 male volunteers aged 60-91.

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  • Maximal increase (MI) of LH and FSH after LHRH stimulation and LH/FSH pulsations (P) over 3 hours were assessed.
  • Participants were classified into four groups based on their LH and T levels.

    • Main Results:

    • Group I (46%) exhibited normal hormonal profiles without hypogonadism.
    • Group II (15%) showed high LH with normal T, indicating a potential compensatory mechanism.
    • Group III (22%) presented with hypergonadotropic hypogonadism (high LH, low T).
    • Group IV (16.5%) displayed hypogonadotropic hypogonadism (low LH, low T).
    • Hormonal profiles and associated conditions in aging men are highly variable.

    Conclusions:

    • Andropause is not a universal or obligatory event in aging men.
    • The hormonal and etiological aspects of andropause are diverse, unlike menopause in women.
    • The study identified distinct endocrine profiles in aging men, highlighting the complexity of age-related hormonal changes.