Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bone scintigraphy in scurvy.

D Front, R Hardoff, J Levy

    Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
    |August 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The XENONnT dark matter experiment.

    The European physical journal. C, Particles and fields·2024
    Same author

    The influence of oral insulin on the development of autoimmune diabetes in NOD mice fed a hypoallergenic diet.

    Diabetes, nutrition & metabolism·2004
    Same author

    An all-digital nuclear medicine department. 1983 [classical article].

    Journal of digital imaging·2003
    Same author

    The expurgation of medical books in sixteenth-century Spain.

    Bulletin of the history of medicine·2001
    Same author

    Quantitative bone single-photon emission computed tomography for prediction of pain relief in metastatic bone disease treated with rhenium-186 etidronate.

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2000
    Same author

    Aggressive non-Hodgkin lymphoma: early prediction of outcome with 67Ga scintigraphy.

    Radiology·2000
    Same journal

    Overall Survival with [<sup>177</sup>Lu]Lu-PSMA-617 Versus [<sup>177</sup>Lu]Lu-PSMA I&T: A Propensity Score-Matched Real-World Analysis.

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2026
    Same journal

    Toward a Biopsy-Free Diagnosis of Prostate Cancer: Potential of Combined <sup>18</sup>F-Flotufolastat PSMA PET and mpMRI.

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2026
    Same journal

    PSMA PET/CT-Targeted Biopsy in Men with Negative or Equivocal Multiparametric MRI and Exploratory Dynamic Total-Body PET: The FUPERMAN Study.

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2026
    Same journal

    Erratum.

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2026
    Same journal

    Live from 2026 SNMMI Annual Meeting in Los Angeles!

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2026
    Same journal

    CAR T-Cell Therapy for Cancer: Updates and Challenges for Response Assessment.

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2026
    See all related articles

    Scurvy can cause distinct bone changes visible on scintigraphy, specifically subperiosteal hematomas in the femur. These changes show increased radiotracer uptake, leading to a characteristic "club-shaped" appearance in advanced stages.

    Area of Science:

    • Medical Imaging
    • Pediatric Radiology
    • Skeletal Diseases

    Background:

    • Scurvy, a vitamin C deficiency disease, can manifest with skeletal abnormalities.
    • Subperiosteal hematomas are a known complication of scurvy.
    • Bone scintigraphy is a sensitive imaging modality for detecting metabolic bone activity.

    Observation:

    • Two pediatric cases of scurvy presented with characteristic scintigraphic bone changes.
    • Early disease stages showed generalized increased radiotracer uptake in the affected femur.
    • Late disease stages revealed marked uptake in the femoral shaft and surrounding tissues.

    Findings:

    • Scintigraphy revealed subperiosteal hematomas as the cause of bone changes in scurvy.
    • The imaging findings evolved from generalized increased uptake to localized intense uptake.

    Related Experiment Videos

  • A distinctive "club-shaped" appearance of the femur was observed in advanced scurvy.

    • Implications:

    • Bone scintigraphy can aid in the diagnosis of scurvy by visualizing characteristic skeletal changes.
    • Understanding these scintigraphic findings is crucial for accurate diagnosis and management of scurvy.
    • This highlights the utility of nuclear medicine in diagnosing nutritional deficiencies affecting bone.