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Implanted cochlear prosthesis analogue in primates.

T J Balkany, R E Mischke, J D Pauley

    Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
    |July 1, 1980
    PubMed
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    Researchers studied the biologic effects of electrical stimulation in the auditory system using a new implantable device in monkeys. Findings showed evidence of bone growth (osteogenesis) in the cochlea after implantation.

    Area of Science:

    • Biomedical Engineering
    • Otolaryngology
    • Neuroscience

    Background:

    • Profound deafness is treated with electronic cochlear prostheses.
    • The biologic effects of electrical stimulation on the auditory system are not well understood.

    Purpose of the Study:

    • To investigate the biologic effects of intracochlear electrical stimulation.
    • To test a newly designed, miniaturized, totally implantable constant-current device in vivo.
    • To assess the feasibility of primate models for cochlear implant research.

    Main Methods:

    • A totally implantable constant-current electronic device was designed and miniaturized.
    • The device was implanted in two Macaca nemestrina monkeys.
    • Histopathologic analysis, including scanning electron microscopy, was performed on the implanted cochlea.

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    Main Results:

    • The device's characteristics were documented.
    • Primate implantation, behavioral observation, and histopathologic study were feasible.
    • Evidence of osteogenesis (bone formation) in the scala tympani was observed in the implanted cochlea.

    Conclusions:

    • The study successfully demonstrated the feasibility of using a novel implantable device for studying electrical stimulation effects in the auditory system.
    • Findings suggest potential biologic responses, such as osteogenesis, to intracochlear electrical stimulation.