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Meningioma with pseudoglandular pattern. A case report
Abstract:
A falx meningioma in an 11-year-old girl had a hemangiopericytomatous and papillary pattern, but the dominant histologic feature was a pseudoglandular arrangement of the tumor cells, closely imitating an adenocarcinoma. The gland-like spaces resulted mainly from dissolution of the centers of cell nests, and to a lesser extent from the fusion of papillary processes. The tumor-recurred locally five years after surgery and maintained its pseudoglandular pattern. Recognition of the existence of a pseudoglandular variant of meningiomas can prevent the mistaken diagnosis of a metastatic adenocarcinoma and other similar tumors.
Insights
A rare falx meningioma mimicked adenocarcinoma due to its pseudoglandular pattern. Recognizing this variant is crucial to avoid misdiagnosis of metastatic tumors.
Area of Science:
- Neuropathology
- Surgical Pathology
Background:
- Meningiomas are tumors arising from the meninges.
- Histological variants of meningiomas can present diagnostic challenges.
Observation:
- An 11-year-old girl presented with a falx meningioma exhibiting hemangiopericytomatous and papillary features.
- The dominant histologic pattern was a pseudoglandular arrangement, mimicking adenocarcinoma.
Findings:
- Gland-like spaces formed from dissolved cell nest centers and fused papillary processes.
- The meningioma recurred locally five years post-surgery, retaining its pseudoglandular morphology.
Implications:
- Awareness of the pseudoglandular meningioma variant is essential for accurate diagnosis.
- Distinguishing this variant prevents misdiagnosis of metastatic adenocarcinoma and other mimics.