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Related Experiment Videos

Prazosin therapy for refractory variant angina.

D Tzivoni, A Keren, J Benhorin

    American Heart Journal
    |February 1, 1983
    PubMed
    Summary

    Prazosin effectively treated Prinzmetal

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    Area of Science:

    • Cardiology
    • Pharmacology

    Background:

    • Prinzmetal's variant angina is a condition characterized by chest pain due to coronary artery spasms.
    • Patients often experience myocardial infarction and transient ST segment elevation during anginal attacks.
    • Previous treatments including high-dose nifedipine, verapamil, nitrates, and beta blockers were ineffective in this patient cohort.

    Observation:

    • Six patients with refractory Prinzmetal's variant angina were studied.
    • Four patients had a history of variant angina prior to myocardial infarction.
    • All patients experienced recurrent anginal attacks with ST segment elevation post-myocardial infarction.

    Findings:

    • Prazosin, an alpha-1 blocker, combined with low-dose nitrates or nifedipine, abolished or markedly reduced anginal attacks in five out of six patients.
    • The drug was generally well-tolerated, with only one patient discontinuing due to hypotension and dizziness.
    • Discontinuation of prazosin led to symptom exacerbation, while reintroduction resolved attacks, indicating efficacy.

    Implications:

    • Prazosin demonstrates significant potential as a therapeutic option for managing refractory Prinzmetal's variant angina.
    • Further long-term studies are warranted to fully evaluate the sustained efficacy and safety of prazosin in this condition.
    • This study highlights the role of alpha-adrenergic blockade in managing specific types of refractory angina.

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