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Related Experiment Videos

A suspected case of codeine-induced erythema multiforme.

C D Ponte

    Drug Intelligence & Clinical Pharmacy
    |February 1, 1983
    PubMed
    Summary

    Erythema multiforme, a skin reaction, can be triggered by medications like codeine. Discontinuing the drug and using antihistamines like hydroxyzine can quickly resolve the rash.

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    Area of Science:

    • Dermatology
    • Pediatric Medicine

    Background:

    • Erythema multiforme is an acute inflammatory condition affecting skin and mucous membranes.
    • It can be associated with various illnesses and drug exposures.

    Observation:

    • A two-year-old child presented with a characteristic erythema multiforme rash.
    • The child had been treated with Actifed-C Expectorant for a suspected viral infection.
    • No mucous membrane involvement was noted.

    Findings:

    • The rash resolved rapidly after discontinuing codeine-containing medication.
    • Hydroxyzine administration appeared to aid in symptom abatement.
    • A viral etiology could not be definitively excluded.

    Implications:

    • Discontinuation of the causative drug is crucial for managing drug-induced erythema multiforme.
    • Antihistamines may provide symptomatic relief.
    • Systemic corticosteroids may be required for severe presentations.

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