Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

An elastic loading system for ventilatory studies in small animals.

W A LaFramboise, R E Tuck, T A Standaert

    Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
    |January 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Growth and development of the term and premature pig-tailed macaque (Macaca nemestrina): Cardiovascular and respiratory changes during the first 3 weeks of life.

    American journal of primatology·2020
    Same author

    A survey of fetal care centers in the United States.

    Journal of neonatal-perinatal medicine·2014
    Same author

    Clinical integration of next-generation sequencing technology.

    Clinics in laboratory medicine·2012
    Same author

    Proteins secreted by embryonic stem cells activate cardiomyocytes through ligand binding pathways.

    Journal of proteomics·2010
    Same author

    Acute molecular response of mouse hindlimb muscles to chronic stimulation.

    American journal of physiology. Cell physiology·2009
    Same author

    Gene expression changes in peripheral blood mononuclear cells from multiple sclerosis patients undergoing beta-interferon therapy.

    Journal of the neurological sciences·2007
    Same journal

    Metabolic control of cardiac output response to exercise in McArdle's disease.

    Journal of applied physiology: respiratory, environmental and exercise physiology·1984
    Same journal

    Hypoxic insomnia: effects of carbon monoxide and acclimatization.

    Journal of applied physiology: respiratory, environmental and exercise physiology·1984
    Same journal

    Quiet-breathing vs. panting methods for determination of specific airway conductance.

    Journal of applied physiology: respiratory, environmental and exercise physiology·1984
    Same journal

    A new method for raising neonatal rabbits in a hypoxic environment.

    Journal of applied physiology: respiratory, environmental and exercise physiology·1984
    Same journal

    Modification of the cutaneous vascular response to exercise by local skin temperature.

    Journal of applied physiology: respiratory, environmental and exercise physiology·1984
    Same journal

    Temperature regulation during treadmill exercise in the rat.

    Journal of applied physiology: respiratory, environmental and exercise physiology·1984
    See all related articles

    This study presents a novel system for applying prolonged inspiratory elastic loading in small animals. The system ensures precise control over respiratory mechanics, enabling advanced physiological research.

    Area of Science:

    • Physiology
    • Respiratory Mechanics
    • Animal Models

    Background:

    • Studying respiratory mechanics in small animals presents unique challenges due to small tidal volumes and high respiratory frequencies.
    • Previous methods for applying elastic loading were not optimized for precise control in small animal models.

    Purpose of the Study:

    • To describe a novel system for precise and controlled application of prolonged inspiratory elastic loading in small animals (300-500 g).
    • To enable detailed investigation of respiratory system responses to elastic loading in research settings.

    Main Methods:

    • A voltage comparator triggers a solenoid valve to vent a loading chamber after inspiratory decompression, maintaining constant extrapulmonary elastance.
    • The system features high sensitivity (5 mV) and rapid response time (40 ms), suitable for tidal volumes < 1 ml and respiratory rates > 100 breaths/min.

    Related Experiment Videos

  • The system allows for easy alteration of inspiratory gas composition and includes a device for end-expiratory occlusions.

    • Main Results:

    • The described system accurately delivers constant extrapulmonary elastance during prolonged inspiratory loading.
    • The system's specifications demonstrate suitability for high-frequency ventilation and low tidal volumes characteristic of small animal models.
    • The system facilitates experimental flexibility through adjustable gas mixtures and occlusion capabilities.

    Conclusions:

    • The developed system provides a reliable and adaptable platform for studying the effects of inspiratory elastic loading in small animals.
    • This technology advances the capability to investigate complex respiratory physiology and disease models in small animal research.
    • The system's precision and flexibility support novel research into respiratory control and mechanics.