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Hyperprolactinemia and headaches.

E Kemmann, J R Jones

    American Journal of Obstetrics and Gynecology
    |March 15, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Headaches are common in women with hyperprolactinemia, occurring more frequently than in the general population. These headaches often resemble tension-type headaches and are not directly linked to prolactin levels.

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    Area of Science:

    • Endocrinology
    • Neurology
    • Women's Health

    Background:

    • Hyperprolactinemia, a condition of elevated prolactin levels, is associated with various health issues.
    • Headaches are a common complaint, but their specific association with hyperprolactinemia requires further investigation.

    Purpose of the Study:

    • To investigate the frequency of headaches in women diagnosed with hyperprolactinemia.
    • To compare headache frequency in hyperprolactinemic women to a control group.
    • To explore potential correlations between headache characteristics and prolactin levels.

    Main Methods:

    • Retrospective analysis of 46 women with hyperprolactinemia (excluding those with sellar abnormalities or prior pituitary surgery).
    • Headache frequency was assessed and compared to a control group of 56 women.

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  • Headache characteristics, including onset, type, and severity, were evaluated.

    • Main Results:

    • 58% of hyperprolactinemic women reported weekly or more frequent headaches, significantly higher than the 27% in the control group (p < 0.01).
    • Headaches typically preceded the diagnosis of hyperprolactinemia by years and resembled tension-type headaches.
    • No significant relationship was found between prolactin levels and headache frequency or severity.

    Conclusions:

    • Headaches are a common, often long-standing, associated symptom in women with hyperprolactinemia, even without significant pituitary enlargement.
    • The etiology of these headaches remains unclear, and their therapeutic management warrants further study.
    • The potential role of bromocriptine in managing these headaches requires additional investigation.