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Term decidua response to estradiol and progesterone.
American Journal of Obstetrics and Gynecology
|March 15, 1983
Summary
Progesterone stimulates prolactin production in term decidua, but estradiol has no effect. This progesterone response is absent in decidua from laboring patients, suggesting labor alters hormonal regulation.
Area of Science:
- Reproductive Endocrinology
- Maternal-Fetal Medicine
- Decidual Biology
Background:
- Decidualized endometrium produces immunoreactive prolactin (PRL) throughout pregnancy.
- Progesterone (P) induces decidualization and PRL production, while estradiol (E2) slows this process in vitro.
Purpose of the Study:
- To investigate the hormonal regulation of PRL production in term decidua.
- To determine if progesterone and estradiol influence PRL production in term pregnancies, considering labor status.
Main Methods:
- Term decidual tissue from laboring and non-laboring patients was cultured in explant.
- Tissues were exposed to progesterone (P) and estradiol (E2) or no hormones.
- PRL production was measured over time.
Main Results:
- Progesterone significantly increased PRL production in nonlabor decidua, an effect not inhibited by estradiol.
- Decidua from laboring patients showed no significant PRL response to either P or E2.
- Significant variability in PRL production was observed across all groups.
Conclusions:
- Progesterone remains an initiator and stimulator of PRL production in term decidua.
- Estradiol does not demonstrate a clear effect on term decidual PRL production.
- Progesterone responsiveness is eliminated in decidua exposed to labor, with the timing relative to labor undetermined.