[Influence of erythrocyte destruction kinetics on the dynamic behavior of the erythropoiesis system]

A simple mathematical model was used to analyse the influence of cell destruction kinetics on the dynamics of erythropoietic system. Two ways of erythrocyte destruction were compared: random destruction and destruction of cells at their maximum age. It has been shown that mostly used description of erythrocyte destruction as a random process results in a great stability increase (about three times in the critical feedback coefficient). Oscillations with large periods (20 divided by 200 days) may exist in the system.