[Experimental substantiation of the possible optimization of integrative brain activity by the psychotropic drugs]

The authors studied the influence of psychotropic drugs on nervous process integration corresponding to an external stereotype of the conditioned reflexes. The latter ones were worked out in dogs by the method of motor situational conditioned reflexes. The drugs that block M-choline- and adrenoreceptors (amizyl, amedin, pyrroxan) decreased the integration level. At the same time they optimized conditioned reflex activity and raised the integration coefficient of drugs having different action mechanisms: N-cholinolytic (pediphen), adrenostimulant (sydnocarb), and anticholinesterase (armine). Nootropyl (piracetam) produced the most powerful action. A suggestion is made about chemical heterogeneity of integrative mechanisms of higher nervous activity and about possibilities of optimizing disturbed integration induced by the influences on various neurotransmitter brain systems.