Related Experiment Video
Updated: Jul 14, 2026

Rat Mesentery Angiogenesis Assay
Published on: June 18, 2011
Chronic administration of bombesin stimulates antral gastrin cell proliferation in the rat
Abstract:
Bombesin tetradecapeptide, administered in gelatin twice daily for 1 wk, significantly increased the antral gastrin content in rats by stimulating antral gastrin cell proliferation. The labeling index of gastrin cells after five daily injections of [3H]thymidine given during bombesin treatment was significantly enhanced as compared with controls, while no modification in the pattern of antral somatostatin cell labeling was revealed. Total antral gastrin cell population at the end of bombesin treatment also increased significantly. Morphometric measurements at the electron microscope level showed that the mean size of gastrin cell in the bombesin-treated group was the same as in the control group. The size of gastrin secretory granules and their number per cell did not change. The present findings demonstrate that chronic administration of bombesin induces gastrin cell hyperplasia in the rat.
More Related Videos
Related Concept Videos
Pathophysiology of Peptic Ulcer Disease: Injurious Factors
In the antrum region, G cells secrete the gastrin hormone that binds to gastrin-cholecystokinin-B (CCK2) receptors on parietal and enterochromaffin-like (ECL) cells in the fundic glands. Simultaneously, the vagus nerve releases acetylcholine, which binds to M3...
Hormones Secreted by the Stomach
Each of these hormones secreted by different enteroendocrine cells plays a unique role in digestion. Here are a few examples:
Gastric Phase of Digestion
When food enters the stomach, it stretches the stomach walls and activates stretch receptors. This triggers local reflexes of the enteric nervous system, mediated through the myenteric plexus. These...
Intestinal Phase of Digestion
The arrival of the chyme in the small intestine distends the duodenum, which triggers the enterogastric reflex. This distension...
Gastritis-II: Pathophysiology
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
Gastritis II: Pathophysiology

