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Complexation of procainamide with hydroxide-containing compounds.

V Das Gupta

    Journal of Pharmaceutical Sciences
    |February 1, 1983
    PubMed
    Summary
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    Procainamide forms complexes with sugars like glucose and lactose, particularly at a pH of 4-5.2. These complexes are reversible and do not form in dry mixtures, indicating solution-based interactions.

    Area of Science:

    • Pharmaceutical Chemistry
    • Physical Chemistry

    Background:

    • Procainamide is a medication with potential interactions with various compounds.
    • Understanding drug-excipient interactions is crucial for formulation development.

    Purpose of the Study:

    • To investigate the complexation of procainamide with several hydroxide-containing compounds.
    • To identify the specific conditions and compounds that facilitate procainamide complex formation.

    Main Methods:

    • Studied complexation of procainamide with various compounds including sugars and glycols.
    • Varied solution pH and compound concentrations to determine optimal complexation conditions.
    • Investigated the reversibility of formed complexes.

    Main Results:

    Related Experiment Videos

    • Procainamide formed complexes with glucose, lactose, and maltose, all containing a hemiacetal group.
    • Complex formation was pH-dependent, with an optimum range of 4-5.2.
    • Complexation occurred in solution but not in dry mixtures; complexes were reversible with acid.

    Conclusions:

    • Procainamide complexation is favored by the presence of hemiacetal groups in compounds like glucose, lactose, and maltose.
    • Solution pH and concentration significantly influence procainamide complex formation.
    • The reversible nature of these complexes is important for pharmaceutical applications.