[Effect of the antioxidant OP-6 on some model reactions of the blood coagulation system]

Formation and lysis of fibrin clot were studied in model systems containing antioxidant OP-6, which is concerned with substances of 3-hydroxypyridine class, using viscosimetry, UV- and IR-spectroscopy. The antioxidant was shown to react with fibrin-monomer molecules shifting an equilibrium of the monomer/polymer/aggregate system towards monomer. OP-6 was able to bind heparin reversibly with formation of the dissociation complex. As shown by biochemical analysis of fibrinogen and fibrin degradation products the antioxidant OP-6 was responsible for inhibition of fibrinolysis and fibrinogenolysis. These data obtained in the model system correlated well with the specific effects of the antioxidant on physiological state of blood coagulation in experimental animals.