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Supplementation frequency and ascorbic acid status in adult males
The American Journal of Clinical Nutrition
|April 1, 1983
Summary
Subjects taking periodic high doses of ascorbic acid (AA) adjusted to maintain similar blood AA levels compared to those taking daily lower doses. This suggests effective periodic supplementation strategies are possible.
Area of Science:
- Nutritional Science
- Biochemistry
Background:
- Ascorbic acid (AA) is essential for human health.
- Understanding optimal AA supplementation strategies is crucial for maintaining adequate levels.
Purpose of the Study:
- To compare blood AA levels in subjects receiving periodic high doses versus daily low doses.
- To determine if periodic AA supplementation can maintain adequate AA levels.
Main Methods:
- Two groups of subjects received different AA dosing regimens over 32 days.
- Serum and white blood cell AA levels were monitored.
- Statistical analysis was used to compare AA levels between groups.
Main Results:
- Initially, all subjects had high habitual AA intake.
- After 32 days, control subjects on low daily doses had low serum AA (<0.7 mg/dl).
- Experimental subjects on periodic high doses adjusted, showing similar or higher AA levels by the third depletion period, with some significantly higher post-dose.
Conclusions:
- Subjects can adjust to periodic high-dose ascorbic acid supplementation.
- Periodic AA dosing may be an effective strategy for maintaining adequate AA levels.
- White blood cell AA levels were negatively correlated with white blood cell count.