Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Morphologic alterations induced by short-term cigarette smoking.

J M Frasca, O Auerbach, H W Carter

    The American Journal of Pathology
    |April 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Expression of group IIa secretory phospholipase A2 increases with prostate tumor grade.

    Clinical cancer research : an official journal of the American Association for Cancer Research·2001
    Same author

    Integrin-linked kinase expression increases with prostate tumor grade.

    Clinical cancer research : an official journal of the American Association for Cancer Research·2001
    Same author

    Validation of the galactose oxidase-Schiff's reagent sequence for early detection and prognosis in human colorectal adenocarcinoma.

    Clinical cancer research : an official journal of the American Association for Cancer Research·1998
    Same author

    Hepatocyte expression of tumor associated aldehyde dehydrogenase (ALDH-3) and p21 Ras following diethylnitrosamine (DEN) initiation and chronic exposure to di(2-ethylhexyl)phthalate (DHEP).

    Carcinogenesis·1996
    Same author

    A comparison between the localization of lung tumors in uranium miners and in nonminers from 1947 to 1991.

    Cancer·1996
    Same author

    Biochemical, pathologic and morphometric alterations induced in male B6C3F1 mouse liver by short-term exposure to dichloroacetic acid.

    Toxicology letters·1995
    Same journal

    Krüppel-like factor 5 inhibition rescues cavernous nerve-injured erectile dysfunction by preventing phenotypic switch and mitochondrial dysfunction-dependent apoptosis in corpus cavernosum smooth muscle cells.

    The American journal of pathology·2026
    Same journal

    Unbiased Spatial Proteomics Uncovers Hepatic in Situ Regulation in Alcohol-Associated Hepatitis.

    The American journal of pathology·2026
    Same journal

    Zinc Finger Protein 143 Promotes Endometriotic Lesion Growth and Fibrosis through the Plasminogen Activator Inhibitor-1 Pathway.

    The American journal of pathology·2026
    Same journal

    Dual Mechanisms Underlie the Repression of Repressor Element 1-Silencing Transcription Factor Expression in Lung Neuroendocrine Carcinoma Cells.

    The American journal of pathology·2026
    Same journal

    Predicting TP53 Biomarkers from Whole Slide Images across Human Solid Tumors Using Weakly Supervised Learning.

    The American journal of pathology·2026
    Same journal

    Metformin Activates AMP-Activated Protein Kinase-Transcription Factor EB Signaling to Restore Lysosomal and Mitochondrial Homeostasis and Suppress Epithelial-to-Mesenchymal Transition in Oxidative Stress-Injured Retinal Pigment Epithelium.

    The American journal of pathology·2026
    See all related articles

    Cigarette smoke exposure in dogs caused pulmonary fibrosis and emphysema. Microscopic lung changes included alveolar destruction and interstitial fibrosis, without early bronchitis.

    Area of Science:

    • Pulmonary Pathology
    • Toxicology
    • Respiratory Medicine

    Background:

    • Cigarette smoking is a major cause of lung disease.
    • Understanding the early pathological changes in the lungs due to smoking is crucial.

    Purpose of the Study:

    • To investigate the early effects of direct cigarette smoke inhalation on canine lungs.
    • To characterize the development of pulmonary fibrosis and emphysema.

    Main Methods:

    • Beagle dogs were exposed to cigarette smoke (2-7 cigarettes/day for 2-4 months).
    • Lung tissues were examined using light and electron microscopy (scanning and transmission).
    • Dogs were sacrificed at different cumulative smoke exposures (172-534 cigarettes).

    Main Results:

    Related Experiment Videos

    • Inhalation produced pulmonary fibrosis and emphysema.
    • Microscopic findings included smoker's macrophages, enlarged alveolar ducts and spaces, and fenestration of alveolar walls.
    • Interstitial fibrosis of interalveolar septa was observed.
    • No evidence of bronchitis, bronchiolitis, or airway obstruction was found in early stages.

    Conclusions:

    • Direct cigarette smoke inhalation can rapidly induce pulmonary fibrosis and emphysema in dogs.
    • Early smoking-induced lung damage involves alveolar destruction and fibrosis.
    • These findings provide insights into the pathogenesis of smoking-related lung diseases.