Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Computer simulation of renal countercurrent systems.

D J Marsh

    Federation Proceedings
    |May 15, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Mathematical models of kidney countercurrent systems are essential for testing urine concentration hypotheses. Models show that active transport in thin ascending limbs is crucial for forming concentrated urine.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Tissue biomarkers of breast cancer and their association with conventional pathologic features.

    British journal of cancer·2013
    Same author

    Dynamics of nephron-vascular network.

    Bulletin of mathematical biology·2012
    Same author

    Metastatic parathyroid carcinoma initially misdiagnosed as parathyroid adenoma: the role of parafibromin in increasing diagnostic accuracy.

    Internal medicine journal·2011
    Same author

    Toe syndactyly revisited.

    Journal of plastic, reconstructive & aesthetic surgery : JPRAS·2010
    Same author

    Mechanism of the anti-obesity effects induced by a novel melanin-concentrating hormone 1-receptor antagonist in mice.

    British journal of pharmacology·2009
    Same author

    Comparative nonlinear modeling of renal autoregulation in rats: Volterra approach versus artificial neural networks.

    IEEE transactions on neural networks·2008
    Same journal

    ASBESTOS FIBERS MEDIATE THE UPTAKE OF DNA INTO PRIMATE CELLS IN CULTURE.

    Federation proceedings·2018
    Same journal

    Chemical protection of mammalian tissues.

    Federation proceedings·2014
    Same journal

    Dietary requirements for fertility and lactation; dried yeasts as sources of proteins and vitamin B complex for growth, reproduction and lactation.

    Federation proceedings·2010
    Same journal

    On the mode of action of chlorinating compounds.

    Federation proceedings·2010
    Same journal

    d-Amino acid oxidase of Proteus morganii.

    Federation proceedings·2010
    Same journal

    Studies on thymus nucleohistone.

    Federation proceedings·2010
    See all related articles

    Area of Science:

    • Nephrology
    • Mathematical Biology
    • Physiology

    Background:

    • The renal countercurrent system is vital for concentrating urine.
    • Mathematical modeling has historically aided in understanding this system.
    • Previous models have been used for parameter estimation and experimental design.

    Purpose of the Study:

    • To evaluate hypotheses regarding the formation of hypertonic urine.
    • To demonstrate the utility of computer simulations with isomorphic models.
    • To test the quantitative sufficiency of different hypotheses for urine concentration.

    Main Methods:

    • Reviewing the history of mathematical modeling of renal countercurrent systems.
    • Citing and discussing examples of model applications.

    Related Experiment Videos

  • Utilizing computer simulations with isomorphic models.
  • Evaluating hypotheses based on quantitative sufficiency.

    • Main Results:

    • Computer simulations serve as an indispensable tool for testing quantitative hypotheses.
    • Hypotheses lacking active transport in thin ascending limbs fail quantitative sufficiency tests.
    • A novel mechanism is proposed where NaCl reabsorption is powered by urea gradient dissipation via antiport.

    Conclusions:

    • Mathematical models are critical for rigorously testing physiological hypotheses.
    • Active transport in the thin ascending limb is a necessary component for hypertonic urine formation.
    • A new model involving urea gradient dissipation offers a potential mechanism for NaCl reabsorption in thin ascending limbs.