Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gc subtypes in Icelanders.

S Karlsson, I Skaftadóttir, A Arnason

    Human Heredity
    |January 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Characteristics of functional movement screening testing in elite handball players: Indicative data from the 9.

    Physical therapy in sport : official journal of the Association of Chartered Physiotherapists in Sports Medicine·2019
    Same author

    Detection efficiency of microchannel plates for e(-) and π(-) in the momentum range from 17.5 to 345 MeV/c.

    The Review of scientific instruments·2015
    Same author

    Improving the mix of institutional and community care for older people with dementia: an application of the balance of care approach in eight European countries.

    Aging & mental health·2015
    Same author

    Disruption of the 5S RNP-Mdm2 interaction significantly improves the erythroid defect in a mouse model for Diamond-Blackfan anemia.

    Leukemia·2015
    Same author

    TGIF1 is a negative regulator of MLL-rearranged acute myeloid leukemia.

    Leukemia·2014
    Same author

    β2-adrenergic stimulation enhances Ca2+ release and contractile properties of skeletal muscles, and counteracts exercise-induced reductions in Na+-K+-ATPase Vmax in trained men.

    The Journal of physiology·2014
    Same journal

    Comparative profiles of pediatric Mendeliome: A Single-Centre 572-Whole-Exome Sequencing Study in Xinjiang.

    Human heredity·2026
    Same journal

    Erratum.

    Human heredity·2026
    Same journal

    Exploratory Analysis of HMGB1 Genetic Variants and Their Potential Association with Lung Cancer Susceptibility and Chemotherapy Response in a Chinese Population.

    Human heredity·2025
    Same journal

    Weighted Burden Analysis of Rare Genetic Variants Identifies Novel Genes with Effects on BMI.

    Human heredity·2025
    Same journal

    Generalized Stable Population and Agent-Based Models of Phenotypic Transmission in Human Populations, with an Application to Body Size.

    Human heredity·2025
    Same journal

    Proteinase-activated receptor 2 (PAR-2) expression and F2RL1 genetic variants are associated with asthma: a case-control study in the Chinese population.

    Human heredity·2025
    See all related articles

    Genetic analysis of Icelanders reveals Gc subtype frequencies, including a unique Gc Iceland variant. This finding contributes to understanding human genetic diversity and population genetics.

    Area of Science:

    • Population Genetics
    • Human Genetics
    • Biochemistry

    Background:

    • The Gc (Vitamin D Binding Protein) system is a polymorphic protein system in human plasma.
    • Understanding Gc subtype frequencies is crucial for population genetics and anthropological studies.
    • Previous studies have established Gc subtype distributions in various populations.

    Purpose of the Study:

    • To determine the gene frequencies of Gc subtypes in the Icelandic population.
    • To identify and characterize any novel Gc variants present in Iceland.
    • To confirm the mode of inheritance for the Gc system in this population.

    Main Methods:

    • Isoelectric focusing (IEF) was employed to analyze Gc protein variants.
    • Gene frequencies were calculated based on the observed subtype phenotypes.

    Related Experiment Videos

  • Family studies (mother-child pairs) were conducted to validate inheritance patterns.

    • Main Results:

    • Observed gene frequencies for Gc subtypes in Icelanders: Gc1F = 0.107, Gc1S = 0.631, Gc2 = 0.262.
    • A novel Icelandic Gc variant allele, Gc Iceland, was identified with a distinct isoelectric point.
    • The Gc Iceland allele was found in 3 unrelated individuals, yielding an allelic frequency of 0.004.
    • Analysis of 65 mother-child pairs supported a three-allelic mode of inheritance for the Gc system.

    Conclusions:

    • The Gc subtype distribution in Icelanders has been established.
    • The discovery of the Gc Iceland variant adds to the known allelic diversity of the Gc system.
    • The findings confirm the genetic basis of Gc subtypes and their inheritance in the Icelandic population.