Immunodeficiency measles encephalitis

The first case of measles encephalitis occurring in an adult with late onset primary hypogammaglobulinaemia is described. This diagnosis was confirmed by examination of the parietal cortex at autopsy with the electron microscope. As the fatal outcome of this case might have been prevented with immunoglobulin replacement therapy, we suggest that such therapy be commenced following the diagnosis even if the patient has only minor infective episodes.