[Morphological changes in rats during short-term chronic poisoning with Karbafos]

The animals were exposed to the shortened chronic poisoning with "Karbafos" in doses 20, 70, 250, and 850 ppm adminstered in fodder during 13 weeks. After the end of experiment, the animals were killed and their organs weighed. In the collected specimens, prepared histologically, were found the increase of the kidney mass and many nonspecific pathomorphotic changes. The pulmonary edema, parenchymatous degeneration in heart, kidneys and liver are--according to the authors--directly connected with "Karbafos" action. The intensification of changes was bound with the size of applied dose of preparation. The investigations allowed to fix the highest tolerance dose of "Karbafos" amounting to 20 ppm.