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Chromosomal aberrations in healthy persons.

S Gundy, L P Varga

    Mutation Research
    |May 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Chromosomal aberrations in peripheral blood lymphocytes were analyzed in 175 healthy adults. A spontaneous aberration frequency of 0.88% per person was observed, establishing a baseline for radiation exposure assessments.

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    Area of Science:

    • Cytogenetics
    • Human genetics
    • Radiation biology

    Background:

    • Chromosomal aberrations in peripheral blood lymphocytes are indicators of genetic damage.
    • Establishing a baseline frequency of these aberrations in a healthy population is crucial for occupational health.
    • Previous studies have varied in their reported frequencies, necessitating updated reference values.

    Purpose of the Study:

    • To determine the spontaneous frequency of chromosomal aberrations in healthy adults.
    • To establish a reference range for aberration levels in a normal population.
    • To provide a basis for evaluating individuals exposed to occupational radiation.

    Main Methods:

    • Peripheral blood lymphocytes were collected from 175 healthy individuals (18-45 years old).

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  • Chromosomal aberration analysis was performed on lymphocyte samples.
  • Frequencies of different aberration types (breaks, fragments, dicentrics) were quantified.

    • Main Results:

    • No aberrations were detected in 113 individuals (64.6%).
    • 154 chromosomal aberrations were found in 62 individuals (35.4%), with frequencies ranging from 1-6% per cell.
    • The average spontaneous aberration frequency was 0.88% per person, comprising chromatid breaks, chromosome fragments, and dicentrics.

    Conclusions:

    • The study established a reference spontaneous frequency of chromosomal aberrations in healthy adults.
    • This reference value is essential for assessing occupational radiation exposure.
    • The findings contribute to understanding baseline genetic damage in the human population.