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Related Experiment Videos

Dimethyl sulfoxide (DMSO) does not affect epidermal wound healing.

O M Goldblum, O M Alvarez, P M Mertz

    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
    |March 1, 1983
    PubMed
    Summary

    Dimethyl sulfoxide (DMSO) at 95% concentration did not significantly impact dermal or epidermal healing in partial-thickness wounds in pigs. Microbial flora also remained unaffected, indicating DMSO is neither beneficial nor harmful for superficial wound repair.

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    Area of Science:

    • Dermatology
    • Wound Healing Research
    • Biochemistry

    Background:

    • Partial-thickness wounds require effective treatments to promote healing and prevent infection.
    • Dimethyl sulfoxide (DMSO) is a solvent with potential therapeutic properties, but its effect on wound healing needs clarification.

    Purpose of the Study:

    • To investigate the impact of 95% DMSO on dermal and epidermal healing processes.
    • To assess the effect of 95% DMSO on the microbial flora of partial-thickness wounds.

    Main Methods:

    • Partial-thickness wounds were created in Yorkshire pigs and treated daily with 95% DMSO, water, or left untreated.
    • Dermal collagen biosynthesis was measured using [14C]hydroxyproline (HP) incorporation and collagenase digestion.
    • Absolute HP content was determined spectrophotometrically.

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  • Epidermal resurfacing was evaluated macroscopically.
  • Bacterial populations were identified and quantified.

    • Main Results:

    • No significant differences were observed in collagen biosynthesis (HP incorporation, absolute collagen content) between DMSO-treated, water-treated, and untreated wounds from Day 2 to Day 6.
    • Epidermal healing and resurfacing showed no significant variations across the treatment groups.
    • The number and types of aerobic bacteria in the wounds were comparable among all groups.

    Conclusions:

    • Topical application of 95% DMSO does not appear to influence collagen biosynthesis or epidermal healing in partial-thickness wounds.
    • DMSO treatment did not alter the microbial flora in the studied wounds.
    • These findings suggest that 95% DMSO is neither beneficial nor detrimental to the healing of superficial wounds.