Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Freezing an extremity in preparation for amputation.

P J Harbrecht, H J Nethery, W Ahmad

    Southern Medical Journal
    |August 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Analyzing optimal control techniques in a nonlinear fractional Rubella model with the Atangana-Baleanu derivative.

    Computers in biology and medicine·2025
    Same author

    Fungal Planet description sheets: 1781-1866.

    Persoonia·2025
    Same author

    Charting achievements: a two-year retrospective of the society for environmental geochemistry and health (SEGH) and the evolving strategies.

    Environmental geochemistry and health·2024
    Same author

    THE COVID-19 PANDEMIC LOCKDOWN'S IMPACT ON ROUTINE CHILDHOOD VACCINATION.

    Georgian medical news·2024
    Same author

    Harmonization service and global library of models to support country-driven global information on salt-affected soils.

    Scientific reports·2023
    Same author

    The psychological burden of disease among patients undergoing cervical spine surgery: Are we underestimating our patients' inherent disability?

    Neuro-Chirurgie·2022

    This study introduces a novel limb-cooling method using antifreeze solution to stabilize gravely ill patients before major amputation. This technique allows for intensive preoperative therapy, improving patient outcomes and enabling limb salvage in select cases.

    Area of Science:

    • Vascular Surgery
    • Nephrology
    • Critical Care Medicine

    Background:

    • Major amputations for ischemia often involve critically ill patients requiring intensive preoperative management.
    • Delaying surgery can allow for stabilization of severe systemic conditions.
    • Physiological amputation via freezing offers a method to achieve this delay.

    Purpose of the Study:

    • To evaluate a novel limb-cooling technique using a pump-circulated antifreeze solution in a specialized boot.
    • To assess the indications and outcomes in 32 patients treated with this method.
    • To identify the benefits of this preoperative therapy in high-risk surgical candidates.

    Main Methods:

    • Developed and utilized a specialized boot system circulating antifreeze solution via a pump.

    Related Experiment Videos

  • Applied the method to 46 patients, with detailed analysis of the last 32.
  • Focused on patient stabilization and optimization prior to major amputation.

    • Main Results:

    • Significant improvements were observed in sepsis control, diabetic coma, chronic renal failure (requiring dialysis), congestive heart failure, and pulmonary function.
    • Four patients achieved successful below-knee amputations after infection control, which previously indicated higher-level amputation.
    • Effective management of pain and odor was noted, alongside reduced nursing care demands.

    Conclusions:

    • The described limb-cooling method provides a safe and efficient means for preoperative stabilization in patients undergoing major amputation for ischemia.
    • This approach facilitates intensive therapy, potentially leading to improved systemic condition, limb salvage, and enhanced patient comfort.
    • The benefits extend to patient well-being and resource utilization, even in cases with poor long-term prognosis due to advanced disease.