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Tuberous sclerosis in old age.

J Gates, J E Jordan

    Southern Medical Journal
    |August 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    This case highlights tuberous sclerosis in an elderly man without seizures, presenting typical lesions and intracranial calcifications. Delayed diagnosis in adults underscores the need for increased awareness of this condition in older populations.

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    Area of Science:

    • Neurology
    • Genetics
    • Dermatology

    Background:

    • Tuberous sclerosis is a genetic disorder typically diagnosed in childhood.
    • The condition is characterized by benign tumors in various organs.
    • Seizures are a common presenting symptom, often leading to early diagnosis.

    Observation:

    • A 64-year-old male presented with tuberous sclerosis without seizures.
    • Clinical manifestations included characteristic cutaneous, retinal, and bone lesions.
    • Intracranial calcifications were noted in the lateral and third ventricles.

    Findings:

    • The absence of seizures in this elderly patient contributed to a delayed diagnosis.
    • The case demonstrates that tuberous sclerosis can manifest in older adults.

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  • Typical physical findings were present despite the atypical presentation regarding seizures.

    • Implications:

    • Increased clinical suspicion for tuberous sclerosis in elderly patients with suggestive lesions is warranted.
    • Prompt diagnosis in adults can facilitate timely management and genetic counseling.
    • This case emphasizes the importance of recognizing tuberous sclerosis beyond its typical pediatric presentation.