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Monocyte tissue factor activity in anticoagulant-treated patients
Thrombosis Research
|January 15, 1983
Summary
Warfarin treatment did not reduce monocyte tissue factor activity, contrary to expectations. In fact, some patients showed elevated levels, suggesting this activity is not always suppressed by anticoagulants.
Area of Science:
- Hematology
- Pharmacology
- Immunology
Background:
- Monocytes play a role in coagulation through tissue factor.
- Warfarin is a common anticoagulant therapy.
- The effect of warfarin on monocyte tissue factor activity is not fully understood.
Purpose of the Study:
- To investigate the effect of long-term warfarin treatment on the tissue factor coagulant activity of peripheral blood monocytes.
- To compare monocyte tissue factor activity in warfarin-treated patients versus healthy individuals.
Main Methods:
- Measurement of tissue factor coagulant activity in peripheral blood monocytes.
- Comparison between 20 patients on warfarin and 21 healthy controls.
Main Results:
- Monocyte tissue factor activity was not reduced in the warfarin-treated group.
- Several warfarin-treated patients exhibited elevated monocyte tissue factor activity.
- No correlation was found between warfarin dosage or prothrombin time and monocyte tissue factor activity.
Conclusions:
- Long-term warfarin therapy does not consistently reduce monocyte tissue factor activity.
- Monocyte tissue factor activity may remain normal or even increase despite warfarin treatment.
- Current anticoagulant strategies may not fully modulate this procoagulant marker on monocytes.