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Related Experiment Videos

Intersubject difference in corneal edema response to hypoxia.

M D Sarver, K A Polse, D A Baggett

    American Journal of Optometry and Physiological Optics
    |February 1, 1983
    PubMed
    Summary

    Some individuals are more susceptible to corneal edema, a swelling of the cornea. This study identified susceptible patients by measuring corneal thickness changes after wearing a specific hydrogel contact lens for three hours.

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    Area of Science:

    • Ophthalmology
    • Corneal Physiology
    • Contact Lens Research

    Background:

    • Clinical observations suggest varying individual susceptibility to corneal edema.
    • Corneal edema, or swelling, can be induced by factors like reduced oxygen availability from contact lens wear.

    Purpose of the Study:

    • To validate the clinical observation of differing patient proneness to corneal edema.
    • To establish a method for identifying individuals predisposed to developing corneal edema.

    Main Methods:

    • Thirty subjects wore an experimental hydrogel lens designed to induce corneal edema by limiting oxygen supply.
    • Corneal thickness changes were measured after 3 hours of open-eye lens wear.
    • Corneal edema response was compared between an experimental lens and a conventional thin hydrogel lens.

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    Main Results:

    • Corneal edema response varied significantly among subjects, ranging from 20.3 to 55.1 microns.
    • High intrasubject reliability (mean +/- 3 microns) was observed in edema measurements.
    • A strong correlation (r = 0.83) was found between edema responses to the experimental and conventional lenses.

    Conclusions:

    • The study confirms that individual susceptibility to corneal edema exists.
    • Measuring corneal thickness changes after a 3-hour trial with a thick HEMA lens can identify susceptible patients.
    • This finding has implications for contact lens fitting and patient management to prevent adverse reactions.