Discrimination of normal and dyskaryotic cells with a new high-resolution system (CIALIS)

Measurements on Feulgen-stained nuclei were performed with a new high-resolution system. Squamous intermediate cells and dyskaryotic cells in cervical smears were compared, based on nuclear features: DNA content, area and two features describing nuclear structure. For data evaluation, a histogram and a linear discriminant analysis were used. The discrimination of the two cell types based on the DNA content and nuclear area was possible to a high degree. A classification based only on the two chosen descriptors of chromatin patterns was not possible.