Relationship between cell size and weight of the human liver. An automated morphometric study

Using a machine-vision system for the analysis of multicolor multicellular images, an algorithm, consisting of cellular logic operators, was developed for estimating the average cross-sectional area of cells in the liver. A total of 28 three-color histologic images from 22 variable-weight autopsied livers were digitized and processed. The data collected showed a positive correlation, albeit weak, between the weight of the liver and the cell size. This correlation was not visually evident, which demonstrates the utility of machine vision in histopathology.