[Hyperplastic changes in the major duodenal papilla in human opisthorchiasis]

Postmortem microscopic examinations and morphometry of the tissue components of the major duodenal papilla in 90 residents of the Tobolsk district who had long time suffered from opisthorchiasis revealed three variants of chronic proliferative papillitis: adenomatous, adenofibroplastic, and sclerosing. They reflect the successive stages of the inflammatory and immunologic reactions of the patients to long-term parasitising of opisthorchiases. Hyperplastic and inflammatory-sclerosing processes in the wall of the papilla ampoule are the main factor in the pathogenesis of diffuse cylindrical cholangiectasia frequently observed in chronic opisthorchiasis.