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Central effects of beta-adrenoceptor antagonists
Clinical Pharmacology and Therapeutics
|January 1, 1983
Summary
Atenolol, a beta-blocker, affects cognitive function and reaction time in healthy individuals. This study demonstrates central nervous system effects of atenolol, impacting psychomotor performance and mood.
Area of Science:
- Neuroscience
- Pharmacology
- Psychopharmacology
Background:
- Atenolol is a cardioselective beta-adrenoceptor antagonist.
- Its central nervous system (CNS) effects in humans are not fully elucidated.
Purpose of the Study:
- To investigate the central effects of atenolol in healthy male subjects.
- To assess the impact of various atenolol doses on psychomotor performance and mood.
Main Methods:
- A randomized, double-blind, crossover study involving six healthy men.
- Administration of placebo, 50, 100, 200, and 400 mg atenolol orally.
- Assessment using psychomotor tests (2FFT, SRT, DCT, SDMT, GSMT) and mood rating scales at multiple time points.
Main Results:
- Atenolol prolonged visual processing (2FFT) and reaction time (SRT) in a dose-dependent manner.
- Cognitive functions measured by DCT and SDMT showed impairment at higher doses.
- Reduced errors in the spiral maze (GSMT) and decreased subjective tension were observed at specific doses.
Conclusions:
- Atenolol exerts significant central effects in humans, impacting cognitive and psychomotor functions.
- Dose-dependent alterations in performance and mood suggest CNS penetration and activity of atenolol.