Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Delayed hypersensitivity skin testing: response rates in a surgical population.

T G Jensen, D M Englert, S J Dudrick

    Journal of the American Dietetic Association
    |January 1, 1983
    PubMed
    Summary

    For accurate skin test results, measure responses at 24 and 48 hours, looking for 5 mm induration. Relying only on 48-hour readings can lead to missed positive skin test reactions.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The impact of depression, anxiety and comorbidity on occupational outcomes.

    Occupational medicine (Oxford, England)·2021
    Same author

    Human placental villi contain stromal macrovesicles associated with networks of stellate cells.

    Journal of anatomy·2019
    Same author

    The relationship between depression symptoms, absenteeism and presenteeism.

    Journal of affective disorders·2019
    Same author

    A smartphone application for treating depressive symptoms: study protocol for a randomised controlled trial.

    BMC psychiatry·2018
    Same author

    A novel method to visualise the three-dimensional organisation of the human cerebral cortical vasculature.

    Journal of anatomy·2018
    Same author

    High-Velocity Microsprays Enhance Antimicrobial Activity in Streptococcus mutans Biofilms.

    Journal of dental research·2016

    Area of Science:

    • Immunology
    • Dermatology
    • Infectious Disease

    Background:

    • Skin testing is a common method for assessing cell-mediated immunity.
    • Standardized protocols for interpreting skin test responses are crucial for accurate diagnosis.

    Purpose of the Study:

    • To determine optimal timing for measuring skin test responses.
    • To establish appropriate criteria for defining a positive skin test reaction.

    Main Methods:

    • Patients received injections of multiple antigens, including streptokinase-streptodornase, mumps, and trichophyton.
    • Skin test responses were evaluated for induration and erythema at both 24 and 48 hours post-injection.

    Main Results:

    • A positive skin test response is defined as induration >= 5 mm at either 24 or 48 hours.

    Related Experiment Videos

  • Measuring responses only at 48 hours risks a significant percentage of false-negative results.
  • Streptokinase-streptodornase, mumps, and trichophyton showed the highest response rates, detecting 94% of positive reactions.

    • Conclusions:

    • Skin test responses should be assessed at both 24 and 48 hours for reliable interpretation.
    • Current 48-hour-only measurement practices are inadequate and may lead to underdiagnosis.
    • Further research is needed to explore erythema as a potential indicator of reactivity.