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Dietary superoxide dismutase does not affect tissue levels.

S Zidenberg-Cherr, C L Keen, B Lönnerdal

    The American Journal of Clinical Nutrition
    |January 1, 1983
    PubMed
    Summary
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    Dietary superoxide dismutase (SOD) supplementation did not alter tissue SOD levels in mice. Oral SOD intake did not impact the activity of key SOD enzymes in various organs or blood.

    Area of Science:

    • Biochemistry
    • Nutrition Science
    • Enzymology

    Background:

    • Superoxide dismutase (SOD) is a crucial antioxidant enzyme.
    • Dietary intake of enzymes is being explored for health benefits.
    • Understanding oral SOD bioavailability is important for its application.

    Purpose of the Study:

    • To investigate the impact of dietary superoxide dismutase (SOD) supplementation on endogenous SOD levels.
    • To determine if oral SOD affects the activity of copper-zinc SOD (CuZn SOD) and manganese SOD (Mn SOD) in various tissues.

    Main Methods:

    • Mice were fed either a standard purified diet (control) or a diet supplemented with 0.004% SOD.
    • Activity of CuZn SOD and Mn SOD was measured in tissue homogenates (intestine, liver, kidney) and blood samples.

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    Main Results:

    • No significant differences were observed in CuZn SOD or Mn SOD activity between the control and SOD-supplemented groups.
    • Tissue SOD levels remained unchanged despite dietary supplementation.

    Conclusions:

    • Oral administration of superoxide dismutase does not increase its activity in mouse tissues.
    • Dietary SOD supplementation is ineffective in enhancing endogenous antioxidant enzyme levels.