IgE and IgD concentrations in patients with recurrent aphthous stomatitis

Serum IgE and IgD concentrations were examined in 80 patients with recurrent aphthous stomatitis (RAS), 20 patients with other ulcerative oral disorders, and 39 control subjects. both IgE and IgD concentrations were substantially greater in patients with RAS than in either the other patients with oral disorders or the control subjects. Although the increased IgE concentrations might be related to cell-mediated phenomena in the immunopathogenesis of RAS and the increased IgD concentrations might support the recently postulated role of IgD in immune responses related to the oral cavity, the possibility that the increased IgE and IgD levels are epiphenomena could not be excluded.