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Updated: Jul 4, 2026

Purification of the Membrane Compartment for Endoplasmic Reticulum-associated Degradation of Exogenous Antigens in Cross-presentation
Published on: August 21, 2017
Mechanisms of lysosomal enzyme secretion by human U-937 monocytes
Abstract:
Lysosomal enzyme secretion was studied in U-937, a mononuclear phagocyte cell line. The secretion of the marker enzyme, beta-N-acetyl-D-glucosaminidase, was low when the cells were challenged with phagocytosable stimuli (asbestos, zymosan, opsonised zymosan). Ammonium chloride and cytochalasin B induced secretion over 24 h of incubation. Phorbol myristate acetate and F-methyl-leucyl-phenylalanine, did not have any effect on secretion. It is suggested that U-937 cells may provide a useful model for the study of mononuclear phagocyte secretory pathways.
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