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Acetate-glucose relationship in growing pigs.

S Imoto, S Namioka

    Journal of Animal Science
    |April 1, 1983
    PubMed
    Summary

    Supplementing pig diets with acetate, in the form of triacetin, altered glucose metabolism. Increased acetate intake lowered plasma glucose and boosted glycogen stores, showing a reciprocal relationship between acetate and glucose metabolism.

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    Area of Science:

    • Animal Science
    • Metabolic Biochemistry
    • Nutritional Physiology

    Background:

    • Acetate is a key energy substrate and precursor for lipogenesis.
    • Understanding acetate's role in glucose homeostasis is crucial for animal nutrition.
    • Dietary acetate influences metabolic pathways in livestock.

    Purpose of the Study:

    • To investigate the relationship between dietary acetate and glucose metabolism in growing pigs.
    • To determine the impact of varying acetate levels on key metabolic indicators.
    • To elucidate the reciprocal changes in acetate and glucose metabolism.

    Main Methods:

    • Crossbred barrows (n=12) were fed diets with 0%, 5%, or 10% supplemental acetate (triacetin).
    • Blood and tissue samples were collected in the immediate and remote postprandial periods.
    • Plasma glucose, lactate, ketone bodies, and tissue glycogen concentrations were analyzed.

    Main Results:

    • Acetate supplementation linearly decreased plasma glucose and increased plasma lactate and ketone bodies.
    • Liver, heart, and muscle glycogen content increased linearly with acetate intake.
    • In the remote period, glucose derived from hepatic glycogen dominated, reducing endogenous acetate production and utilization.

    Conclusions:

    • Dietary acetate influences glucose homeostasis and glycogen storage in pigs.
    • A reciprocal metabolic relationship exists between acetate and glucose.
    • Acetate supplementation alters substrate utilization and energy metabolism in swine.

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