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Hematologic abnormalities in Southeast Asian refugees

J Craft, D Coleman, H O Coulter

    JAMA
    |June 17, 1983
    PubMed

    Insights

    Hematologic abnormalities, including anemia and microcytosis, are common in Southeast Asian refugees. Iron deficiency and inherited hemoglobin disorders are primary causes, detectable by hemoglobin electrophoresis and iron store tests.

    Area of Science:

    • Hematology
    • Public Health
    • Immigrant Health

    Background:

    • Comprehensive medical care has been provided to 142 Southeast Asian refugees resettled in Connecticut since 1979.
    • A significant prevalence of hematologic abnormalities was observed in both adult and pediatric populations within this group.

    Purpose of the Study:

    • To identify and characterize hematologic abnormalities in Southeast Asian refugees.
    • To determine the underlying causes of anemia and microcytosis in this population.
    • To evaluate diagnostic methods for detecting these conditions.

    Main Methods:

    • Analysis of medical records for hematologic parameters.
    • Identification of anemia and microcytosis prevalence.
    • Investigation of causes including iron deficiency and hemoglobin synthesis disorders.
    • Utilizing hemoglobin electrophoresis and serological tests for iron stores.

    Main Results:

    • 18% of the refugee population presented with anemia.
    • 35% exhibited microcytosis.
    • The majority of anemias were microcytic, stemming from iron deficiency or inherited hemoglobin disorders.
    • Inherited hemoglobin disorders were identified in at least 7.5% of the population and were the main cause of microcytosis.

    Conclusions:

    • Microcytic anemia and microcytosis are prevalent hematologic issues in Southeast Asian refugees.
    • Iron deficiency and inherited hemoglobinopathies are key contributors to these findings.
    • Hemoglobin electrophoresis and iron store testing are effective diagnostic tools for identifying anemia causes in this demographic.

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