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Desmosterol in human milk.

R M Clark, M B Fey, R G Jensen

    Lipids
    |March 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Desmosterol, a cholesterol precursor, is present in all human breast milk samples analyzed. Its concentration significantly increases from 2 to 16 weeks postpartum.

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    Area of Science:

    • Biochemistry
    • Human Physiology
    • Lactation Studies

    Background:

    • Cholesterol metabolism plays a vital role in infant development.
    • Understanding the composition of human milk is crucial for infant nutrition.
    • Desmosterol is a known intermediate in cholesterol biosynthesis.

    Purpose of the Study:

    • To determine the presence and concentration of desmosterol in human breast milk.
    • To investigate the changes in desmosterol levels during the postpartum period.
    • To explore potential correlations between desmosterol and other milk lipids.

    Main Methods:

    • Human milk samples were collected at 2, 6, 12, and 16 weeks postpartum.
    • Desmosterol was identified using gas-liquid chromatography (GLC) and GC-mass spectrometry.

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  • Concentrations were quantified and statistically analyzed.

    • Main Results:

    • Desmosterol was detected in all analyzed breast milk samples.
    • A significant increase in desmosterol concentration was observed from 2 weeks (0.6 mg/100 ml) to 16 weeks (1.3 mg/100 ml) postpartum (P < .05).
    • No significant correlation was found between desmosterol levels and total lipid, total cholesterol, or free cholesterol content.

    Conclusions:

    • Desmosterol is a component of human breast milk, with levels increasing over the early postpartum period.
    • The findings suggest a dynamic role for desmosterol in lactation or infant development.
    • Further research is needed to elucidate the specific functions of desmosterol in breast milk.